'Murder not acceptable in NSW': five men arrested over fatal shooting

A member of the Comancheros and four other men have been arrested in connection with the death of a man who was shot multiple times outside a home in Sydney's west.

Emergency services were called to Meridian Place at Doonside about 7.30pm on Monday after reports of a shooting.

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NSW Ambulance paramedics treated Craig Anderson, 51, who had suffered several gunshot wounds, but he died at the scene.

Investigators say that Mr Anderson, who was known to police, had been in a dispute with one of the men over something trivial.

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"The personal nature of this has been escalating for some time," Detective Superintendent Scott Cook told reporters on Tuesday.

"It's not clear what the dispute was over."

Police comforted several people at a house in Meridian Place on Monday who appeared highly distressed.

"Many" neighbours called police after hearing gunshots, Det Supt Cook said.

A crime scene was established, and officers from Blacktown Police Area Command and State Crime Command’s Homicide Squad commenced inquiries.

An hour after the shooting, five men, aged 44, 29, 28, 27, and 22, were arrested after vehicle stops in the St Marys area, police said in a statement on Tuesday.

Police seized four cars and one firearm found in a vehicle.

The 44-year-old and 28-year-old man were taken to St Marys Police Station and the other three were taken to Penrith Police Station. They all continue to assist with inquiries. No charges have been laid.

"Murder is not acceptable in New South Wales," Det Supt Cook said.

"It's not tolerable. This is bad behaviour, not sophisticated organised crime."